Endocrine Abstracts

Background: Innate, isolated hypogonadotropic hypogonadism is a rare disease and results in men in cryptorchidism and failed puberty. Migration leads to diagnosis of the disease also in developed countries only in adults.Case: A 28-year-old man was sent for endocrine workup because of failed development of primary sexual characteristics and missing secondary sex characteristics. He grew up in a rural place in Sri Lanka, his brothers and sisters developed...

Background: Primary adrenal lymphoma (PAL) is a rare cause of primary adrenal insufficiency (PAI). Most often patients present with unspecific symptoms. Bilateral adrenal enlargement with signs and symptoms of PAI are clues, percutaneous biopsy after having excluded pheochromocytoma in a situation of high suspicion is diagnostic. Most of PAL are highly malignant B-cell lymphomas with a bad prognosis.Case: A 71-year-old patient was sent for endocrine work...

Context: Identification of risk factors predicting relapse in patients with hyperthyroidism of Graves’ disease after the first cycle with standard thyreostatic therapy [ATD] is important to guide therapeutic options.Objective: We performed a systematic review and meta-analysis to study predictors for risk of relapse after the first treatment episode with ATD in patients with Graves’ disease induced hyperthyroidism.Data so...

Objective: Whether additional immunosuppressive drugs to standard treatment with thyreostatic drugs reduce the risk for relapse in Graves’ disease is not well understood. We performed a systematic review and meta-analysis to study the effects of immunosuppressive drugs on relapse rate and treatment effect of patients with hyperthyroidism due to Graves’ disease.Methods: We searched PubMed, EMBASE and Cochrane in July 2015 for randomized-controll...

Introduction: Fibroblast growth factor-21 (FGF-21) is a recently discovered hormone acting as a central regulator of metabolism via adaptation of glucose homeostasis, insulin sensitivity, and ketogenesis. While acute systemic inflammatory conditions come along with profound alterations of metabolism, the role of FGF-21 in these acute phase responses is still unknown.Methods: This is a secondary analysis of two randomized, controlled trials in patients pr...

Introduction: Fluid restriction (FR) is often the recommended first-line treatment for hyponatremia due to the syndrome of inappropriate antidiuresis (SIAD). However, FR not always leads to successful correction of hyponatremia, making predictive markers of treatment response desirable. The aim of this study was to evaluate routinely measured laboratory parameters, copeptin and pro-atrial natriuretic peptide (pro-ANP) as possible predictors of treatment success to FR.<p cl...

Background: The water deprivation test as the accepted gold standard in the differential diagnosis of polyuria polydipsia syndrome can be associated with a decrease in extracellular fluid volume in patients with diabetes insipidus (DI). We herein evaluated mid-regional pro-atrial natriuretic peptide (MR-proANP) as marker of extracellular body volume in patients with diabetes insipidus compared to primary polydipsia (PP), at baseline and after water deprivation.<p class="ab...

Background: Hyponatremia is common in hospitalized patients and its differential diagnosis and management challenging. An important mechanism is suppressed or adequately or inadequately secreted plasma arginine vasopressin (AVP). Therefore, plasma vasopressin levels may help in the differential diagnosis and in therapy management. Copeptin is secreted in an equimolar ratio to AVP and is more reliable to measure.Methods: In this prospective observational ...

Background: Hyponatremia is the most common electrolyte disturbance in hospitalized patients and associated with a substantial morbidity and mortality. Symptoms of severe hyponatremia vary among patients between nonspecific symptoms such as nausea or malaise or acute life threatening brain oedema. Prospective studies to assess symptoms and mortality in patients with severe hyponatremia are lacking.Methods: In this prospective multicentre observational st...

Introduction: Hyponatremia is the most common electrolyte abnormality in clinical practice and given its impact on mortality and morbidity a relevant medical condition. Nevertheless little is known about factors influencing long-term outcome.Methods: This is a prospective observational 12 months follow-up study of patients with profound hyponatremia (≤125 mmol/l) admitted to the medical emergency department of two tertiary care centers in Switzerla...